CD46 facilitates entry and dissemination of human cytomegalovirus

Human cytomegalovirus (CMV) infects a wide range of host cells. Here, using a high throughput antibody screening platform, the authors identify the cell surface receptor CD46 to be required for CMV infection of epithelial cells and trophoblast-derived cells, the latter critical for congenital CMV in...

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Autores principales:	Kathryn R. Stein, Thomas J. Gardner, Rosmel E. Hernandez, Thomas A. Kraus, James A. Duty, Iban Ubarretxena-Belandia, Thomas M. Moran, Domenico Tortorella
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8106cc357234409b93e70c97eb7e4ea3
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spelling	oai:doaj.org-article:8106cc357234409b93e70c97eb7e4ea32021-12-02T16:50:58ZCD46 facilitates entry and dissemination of human cytomegalovirus10.1038/s41467-019-10587-12041-1723https://doaj.org/article/8106cc357234409b93e70c97eb7e4ea32019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10587-1https://doaj.org/toc/2041-1723Human cytomegalovirus (CMV) infects a wide range of host cells. Here, using a high throughput antibody screening platform, the authors identify the cell surface receptor CD46 to be required for CMV infection of epithelial cells and trophoblast-derived cells, the latter critical for congenital CMV infection.Kathryn R. SteinThomas J. GardnerRosmel E. HernandezThomas A. KrausJames A. DutyIban Ubarretxena-BelandiaThomas M. MoranDomenico TortorellaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathryn R. Stein Thomas J. Gardner Rosmel E. Hernandez Thomas A. Kraus James A. Duty Iban Ubarretxena-Belandia Thomas M. Moran Domenico Tortorella CD46 facilitates entry and dissemination of human cytomegalovirus
description	Human cytomegalovirus (CMV) infects a wide range of host cells. Here, using a high throughput antibody screening platform, the authors identify the cell surface receptor CD46 to be required for CMV infection of epithelial cells and trophoblast-derived cells, the latter critical for congenital CMV infection.
format	article
author	Kathryn R. Stein Thomas J. Gardner Rosmel E. Hernandez Thomas A. Kraus James A. Duty Iban Ubarretxena-Belandia Thomas M. Moran Domenico Tortorella
author_facet	Kathryn R. Stein Thomas J. Gardner Rosmel E. Hernandez Thomas A. Kraus James A. Duty Iban Ubarretxena-Belandia Thomas M. Moran Domenico Tortorella
author_sort	Kathryn R. Stein
title	CD46 facilitates entry and dissemination of human cytomegalovirus
title_short	CD46 facilitates entry and dissemination of human cytomegalovirus
title_full	CD46 facilitates entry and dissemination of human cytomegalovirus
title_fullStr	CD46 facilitates entry and dissemination of human cytomegalovirus
title_full_unstemmed	CD46 facilitates entry and dissemination of human cytomegalovirus
title_sort	cd46 facilitates entry and dissemination of human cytomegalovirus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8106cc357234409b93e70c97eb7e4ea3
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CD46 facilitates entry and dissemination of human cytomegalovirus

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