α1-Antitrypsin attenuates acute rejection of orthotopic murine lung allografts

α1-Antitrypsin attenuates acute rejection of orthotopic murine lung allografts

Abstract Background α1-Antitrypsin (AAT) is an acute phase glycoprotein, a multifunctional protein with proteinase inhibitory, anti-inflammatory and cytoprotective properties. Both preclinical and clinical experiences show that the therapy with plasma purified AAT is beneficial for a broad spectrum...

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Autores principales: Tomoyuki Nakagiri, Sabine Wrenger, Kokilavani Sivaraman, Fabio Ius, Tobias Goecke, Patrick Zardo, Veronika Grau, Tobias Welte, Axel Haverich, Ann-Kathrin Knöfel, Sabina Janciauskiene
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Lung transplantation
Acute allograft rejection
Mouse orthotopic single lung transplantation model
Primary graft dysfunction
Alpha1-antitrypsin
Diseases of the respiratory system
RC705-779
Acceso en línea:https://doaj.org/article/81338e3554414e0a80aaf3bb0be142c3
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https://doaj.org/article/81338e3554414e0a80aaf3bb0be142c3

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