Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS

The low-complexity (LC) domain mediates liquid-liquid phase separation and fibril formation of the RNA-binding protein FUS (FUsed in Sarcoma). Here, the authors combine cryo-EM, solid-state NMR measurements and MD simulations to structurally characterise the fibrils formed by the C-terminal half of...

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Autores principales: Myungwoon Lee, Ujjayini Ghosh, Kent R. Thurber, Masato Kato, Robert Tycko
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8142805573524157b65818c9f357da0e
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