Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression

Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression

Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis when metastatic and scarce treatment options in the advanced stages. In solid tumors, the chemokine CXCL12/CXCR4 axis is involved in the metastatic process. We demonstrated that the human adrenocortex expressed CXCL12 and its co...

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Bibliographic Details
Main Authors: Giulia Cantini, Laura Fei, Letizia Canu, Elena Lazzeri, Mariangela Sottili, Michela Francalanci, Maria Lucia Angelotti, Giuseppina De Filpo, Tonino Ercolino, Stefania Gelmini, Monica Mangoni, Gabriella Nesi, Constanze Hantel, Massimo Mannelli, Mario Maggi, Michaela Luconi
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
chemokines
rare cancers
ACC
xenograft cancer models
anti-cancer therapy
thiazolidinediones
Medicine
R
Online Access:https://doaj.org/article/814e9f34ad2c4aa8be3f47d9b86d050b
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