Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

G protein-coupled receptors are considered promising therapeutic targets. Here, the authors have identified nanobodies, or single-domain llama antibodies, that specifically enhance agonist-induced activity of a type of G protein-coupled receptor, the mGlu2 receptor.

Guardado en:

Detalles Bibliográficos
Autores principales:	Pauline Scholler, Damien Nevoltris, Dimitri de Bundel, Simon Bossi, David Moreno-Delgado, Xavier Rovira, Thor C. Møller, Driss El Moustaine, Michaël Mathieu, Emilie Blanc, Heather McLean, Elodie Dupuis, Gérard Mathis, Eric Trinquet, Hervé Daniel, Emmanuel Valjent, Daniel Baty, Patrick Chames, Philippe Rondard, Jean-Philippe Pin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/816648732d614ed3bfb0746f18dd9438
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:816648732d614ed3bfb0746f18dd9438
record_format	dspace
spelling	oai:doaj.org-article:816648732d614ed3bfb0746f18dd94382021-12-02T17:06:18ZAllosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation10.1038/s41467-017-01489-12041-1723https://doaj.org/article/816648732d614ed3bfb0746f18dd94382017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01489-1https://doaj.org/toc/2041-1723G protein-coupled receptors are considered promising therapeutic targets. Here, the authors have identified nanobodies, or single-domain llama antibodies, that specifically enhance agonist-induced activity of a type of G protein-coupled receptor, the mGlu2 receptor.Pauline SchollerDamien NevoltrisDimitri de BundelSimon BossiDavid Moreno-DelgadoXavier RoviraThor C. MøllerDriss El MoustaineMichaël MathieuEmilie BlancHeather McLeanElodie DupuisGérard MathisEric TrinquetHervé DanielEmmanuel ValjentDaniel BatyPatrick ChamesPhilippe RondardJean-Philippe PinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pauline Scholler Damien Nevoltris Dimitri de Bundel Simon Bossi David Moreno-Delgado Xavier Rovira Thor C. Møller Driss El Moustaine Michaël Mathieu Emilie Blanc Heather McLean Elodie Dupuis Gérard Mathis Eric Trinquet Hervé Daniel Emmanuel Valjent Daniel Baty Patrick Chames Philippe Rondard Jean-Philippe Pin Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
description	G protein-coupled receptors are considered promising therapeutic targets. Here, the authors have identified nanobodies, or single-domain llama antibodies, that specifically enhance agonist-induced activity of a type of G protein-coupled receptor, the mGlu2 receptor.
format	article
author	Pauline Scholler Damien Nevoltris Dimitri de Bundel Simon Bossi David Moreno-Delgado Xavier Rovira Thor C. Møller Driss El Moustaine Michaël Mathieu Emilie Blanc Heather McLean Elodie Dupuis Gérard Mathis Eric Trinquet Hervé Daniel Emmanuel Valjent Daniel Baty Patrick Chames Philippe Rondard Jean-Philippe Pin
author_facet	Pauline Scholler Damien Nevoltris Dimitri de Bundel Simon Bossi David Moreno-Delgado Xavier Rovira Thor C. Møller Driss El Moustaine Michaël Mathieu Emilie Blanc Heather McLean Elodie Dupuis Gérard Mathis Eric Trinquet Hervé Daniel Emmanuel Valjent Daniel Baty Patrick Chames Philippe Rondard Jean-Philippe Pin
author_sort	Pauline Scholler
title	Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
title_short	Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
title_full	Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
title_fullStr	Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
title_full_unstemmed	Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
title_sort	allosteric nanobodies uncover a role of hippocampal mglu2 receptor homodimers in contextual fear consolidation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/816648732d614ed3bfb0746f18dd9438
work_keys_str_mv	AT paulinescholler allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT damiennevoltris allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT dimitridebundel allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT simonbossi allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT davidmorenodelgado allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT xavierrovira allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT thorcmøller allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT drisselmoustaine allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT michaelmathieu allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT emilieblanc allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT heathermclean allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT elodiedupuis allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT gerardmathis allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT erictrinquet allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT hervedaniel allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT emmanuelvaljent allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT danielbaty allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT patrickchames allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT philipperondard allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation AT jeanphilippepin allostericnanobodiesuncoveraroleofhippocampalmglu2receptorhomodimersincontextualfearconsolidation
_version_	1718381684190085120

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

Ejemplares similares