A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors

While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well described. We previously found through a bead-base...

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Autores principales: Klara Klein, Angelique Hölzemer, Tim Wang, Tae-Eun Kim, Haley L. Dugan, Stephanie Jost, Marcus Altfeld, Wilfredo F. Garcia-Beltran
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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KIR
Acceso en línea:https://doaj.org/article/817f14afd14f4171ab4d81ffe9b0d460
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