Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity

ABSTRACT The 2′,5′-oligoadenylate (2-5A)-dependent endoribonuclease, RNase L, is a principal mediator of the interferon (IFN) antiviral response. Therefore, the regulation of cellular levels of 2-5A is a key point of control in antiviral innate immunity. Cellular 2-5A levels are determined by IFN-in...

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Auteurs principaux: Abhishek Asthana, Christina Gaughan, Beihua Dong, Susan R. Weiss, Robert H. Silverman
Format: article
Langue:EN
Publié: American Society for Microbiology 2021
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OAS
Accès en ligne:https://doaj.org/article/817fafeb64f249a9b658828a1f2de837
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