Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

When cells acquire a malignant phenotype they become less stiff and this helps migration and invasion favouring metastasis. Here the authors show that Src-driven cell transformation and transition to a less stiff state follows an event of membrane stiffening due to stress fibres accumulation.

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Bibliographic Details
Main Authors: Sandra Tavares, André Filipe Vieira, Anna Verena Taubenberger, Margarida Araújo, Nuno Pimpao Martins, Catarina Brás-Pereira, António Polónia, Maik Herbig, Clara Barreto, Oliver Otto, Joana Cardoso, José B. Pereira-Leal, Jochen Guck, Joana Paredes, Florence Janody
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
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Online Access:https://doaj.org/article/81895e0259f64593b8f9d2d82c68edd5
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Internet

https://doaj.org/article/81895e0259f64593b8f9d2d82c68edd5

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