Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

When cells acquire a malignant phenotype they become less stiff and this helps migration and invasion favouring metastasis. Here the authors show that Src-driven cell transformation and transition to a less stiff state follows an event of membrane stiffening due to stress fibres accumulation.

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Autores principales:	Sandra Tavares, André Filipe Vieira, Anna Verena Taubenberger, Margarida Araújo, Nuno Pimpao Martins, Catarina Brás-Pereira, António Polónia, Maik Herbig, Clara Barreto, Oliver Otto, Joana Cardoso, José B. Pereira-Leal, Jochen Guck, Joana Paredes, Florence Janody
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81895e0259f64593b8f9d2d82c68edd5
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spelling	oai:doaj.org-article:81895e0259f64593b8f9d2d82c68edd52021-12-02T14:40:36ZActin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells10.1038/ncomms152372041-1723https://doaj.org/article/81895e0259f64593b8f9d2d82c68edd52017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15237https://doaj.org/toc/2041-1723When cells acquire a malignant phenotype they become less stiff and this helps migration and invasion favouring metastasis. Here the authors show that Src-driven cell transformation and transition to a less stiff state follows an event of membrane stiffening due to stress fibres accumulation.Sandra TavaresAndré Filipe VieiraAnna Verena TaubenbergerMargarida AraújoNuno Pimpao MartinsCatarina Brás-PereiraAntónio PolóniaMaik HerbigClara BarretoOliver OttoJoana CardosoJosé B. Pereira-LealJochen GuckJoana ParedesFlorence JanodyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandra Tavares André Filipe Vieira Anna Verena Taubenberger Margarida Araújo Nuno Pimpao Martins Catarina Brás-Pereira António Polónia Maik Herbig Clara Barreto Oliver Otto Joana Cardoso José B. Pereira-Leal Jochen Guck Joana Paredes Florence Janody Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
description	When cells acquire a malignant phenotype they become less stiff and this helps migration and invasion favouring metastasis. Here the authors show that Src-driven cell transformation and transition to a less stiff state follows an event of membrane stiffening due to stress fibres accumulation.
format	article
author	Sandra Tavares André Filipe Vieira Anna Verena Taubenberger Margarida Araújo Nuno Pimpao Martins Catarina Brás-Pereira António Polónia Maik Herbig Clara Barreto Oliver Otto Joana Cardoso José B. Pereira-Leal Jochen Guck Joana Paredes Florence Janody
author_facet	Sandra Tavares André Filipe Vieira Anna Verena Taubenberger Margarida Araújo Nuno Pimpao Martins Catarina Brás-Pereira António Polónia Maik Herbig Clara Barreto Oliver Otto Joana Cardoso José B. Pereira-Leal Jochen Guck Joana Paredes Florence Janody
author_sort	Sandra Tavares
title	Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
title_short	Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
title_full	Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
title_fullStr	Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
title_full_unstemmed	Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
title_sort	actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/81895e0259f64593b8f9d2d82c68edd5
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Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

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