Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy.

Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy.

Mice cannot be used to evaluate HIV-1 therapeutics and vaccines because they are not infectible by HIV-1 due to structural differences between several human and mouse proteins required for HIV-1 entry and replication including CD4, CCR5 and cyclin T1. We overcame this limitation by constructing mice...

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Bibliographic Details
Main Authors: Kieran Seay, Xiaohua Qi, Jian Hua Zheng, Cong Zhang, Ken Chen, Monica Dutta, Kathryn Deneroff, Christina Ochsenbauer, John C Kappes, Dan R Littman, Harris Goldstein
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/81ace1bf4b8b412ab2052854cde06e08
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https://doaj.org/article/81ace1bf4b8b412ab2052854cde06e08

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