Translation error clusters induced by aminoglycoside antibiotics

Aminoglycoside antibiotics target the ribosome and induce misreading, yet which translation errors induce bacterial cell death is unclear. Here authors use quantitative mass spectrometry and show that bactericidal aminoglycosides induce clusters of errors in full-length proteins in vivo with as many...

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Autores principales: Ingo Wohlgemuth, Raffaella Garofalo, Ekaterina Samatova, Aybeg Nafiz Günenç, Christof Lenz, Henning Urlaub, Marina V. Rodnina
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/81c575edaca14f1fa23d9fc498664242
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