Translation error clusters induced by aminoglycoside antibiotics

Aminoglycoside antibiotics target the ribosome and induce misreading, yet which translation errors induce bacterial cell death is unclear. Here authors use quantitative mass spectrometry and show that bactericidal aminoglycosides induce clusters of errors in full-length proteins in vivo with as many...

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Autores principales:	Ingo Wohlgemuth, Raffaella Garofalo, Ekaterina Samatova, Aybeg Nafiz Günenç, Christof Lenz, Henning Urlaub, Marina V. Rodnina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81c575edaca14f1fa23d9fc498664242
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spelling	oai:doaj.org-article:81c575edaca14f1fa23d9fc4986642422021-12-02T16:36:00ZTranslation error clusters induced by aminoglycoside antibiotics10.1038/s41467-021-21942-62041-1723https://doaj.org/article/81c575edaca14f1fa23d9fc4986642422021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21942-6https://doaj.org/toc/2041-1723Aminoglycoside antibiotics target the ribosome and induce misreading, yet which translation errors induce bacterial cell death is unclear. Here authors use quantitative mass spectrometry and show that bactericidal aminoglycosides induce clusters of errors in full-length proteins in vivo with as many as four amino acid substitutions in a row.Ingo WohlgemuthRaffaella GarofaloEkaterina SamatovaAybeg Nafiz GünençChristof LenzHenning UrlaubMarina V. RodninaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ingo Wohlgemuth Raffaella Garofalo Ekaterina Samatova Aybeg Nafiz Günenç Christof Lenz Henning Urlaub Marina V. Rodnina Translation error clusters induced by aminoglycoside antibiotics
description	Aminoglycoside antibiotics target the ribosome and induce misreading, yet which translation errors induce bacterial cell death is unclear. Here authors use quantitative mass spectrometry and show that bactericidal aminoglycosides induce clusters of errors in full-length proteins in vivo with as many as four amino acid substitutions in a row.
format	article
author	Ingo Wohlgemuth Raffaella Garofalo Ekaterina Samatova Aybeg Nafiz Günenç Christof Lenz Henning Urlaub Marina V. Rodnina
author_facet	Ingo Wohlgemuth Raffaella Garofalo Ekaterina Samatova Aybeg Nafiz Günenç Christof Lenz Henning Urlaub Marina V. Rodnina
author_sort	Ingo Wohlgemuth
title	Translation error clusters induced by aminoglycoside antibiotics
title_short	Translation error clusters induced by aminoglycoside antibiotics
title_full	Translation error clusters induced by aminoglycoside antibiotics
title_fullStr	Translation error clusters induced by aminoglycoside antibiotics
title_full_unstemmed	Translation error clusters induced by aminoglycoside antibiotics
title_sort	translation error clusters induced by aminoglycoside antibiotics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81c575edaca14f1fa23d9fc498664242
work_keys_str_mv	AT ingowohlgemuth translationerrorclustersinducedbyaminoglycosideantibiotics AT raffaellagarofalo translationerrorclustersinducedbyaminoglycosideantibiotics AT ekaterinasamatova translationerrorclustersinducedbyaminoglycosideantibiotics AT aybegnafizgunenc translationerrorclustersinducedbyaminoglycosideantibiotics AT christoflenz translationerrorclustersinducedbyaminoglycosideantibiotics AT henningurlaub translationerrorclustersinducedbyaminoglycosideantibiotics AT marinavrodnina translationerrorclustersinducedbyaminoglycosideantibiotics
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Translation error clusters induced by aminoglycoside antibiotics

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