High content screening identifies monensin as an EMT-selective cytotoxic compound

Abstract Epithelial-to-mesenchymal transition (EMT) is implicated in cancer metastasis and drug resistance. Specifically targeting cancer cells in an EMT-like state may have therapeutic value. In this study, we developed a cell imaging-based high-content screening protocol to identify EMT-selective...

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Auteurs principaux: Marion Vanneste, Qin Huang, Mengshi Li, Devon Moose, Lei Zhao, Mark A. Stamnes, Michael Schultz, Meng Wu, Michael D. Henry
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/81d4fbdb3f094595b0c61a1302ce2102
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