Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining

Classical non-homologous end-joining (cNHEJ) is the dominant pathway used by human cells to repair DNA double-strand breaks (DSBs) and maintain genome stability. Here the authors show that PARP1-driven chromatin expansion allows the recruitment of ZNF384, which in turn recruits Ku70/Ku80 to facilita...

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Autores principales:	Jenny Kaur Singh, Rebecca Smith, Magdalena B. Rother, Anton J. L. de Groot, Wouter W. Wiegant, Kees Vreeken, Ostiane D’Augustin, Robbert Q. Kim, Haibin Qian, Przemek M. Krawczyk, Román González-Prieto, Alfred C. O. Vertegaal, Meindert Lamers, Sébastien Huet, Haico van Attikum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81eb6422ad4941fe875820f223a85fd7
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spelling	oai:doaj.org-article:81eb6422ad4941fe875820f223a85fd72021-11-14T12:34:17ZZinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining10.1038/s41467-021-26691-02041-1723https://doaj.org/article/81eb6422ad4941fe875820f223a85fd72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26691-0https://doaj.org/toc/2041-1723Classical non-homologous end-joining (cNHEJ) is the dominant pathway used by human cells to repair DNA double-strand breaks (DSBs) and maintain genome stability. Here the authors show that PARP1-driven chromatin expansion allows the recruitment of ZNF384, which in turn recruits Ku70/Ku80 to facilitate cNHEJ.Jenny Kaur SinghRebecca SmithMagdalena B. RotherAnton J. L. de GrootWouter W. WiegantKees VreekenOstiane D’AugustinRobbert Q. KimHaibin QianPrzemek M. KrawczykRomán González-PrietoAlfred C. O. VertegaalMeindert LamersSébastien HuetHaico van AttikumNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jenny Kaur Singh Rebecca Smith Magdalena B. Rother Anton J. L. de Groot Wouter W. Wiegant Kees Vreeken Ostiane D’Augustin Robbert Q. Kim Haibin Qian Przemek M. Krawczyk Román González-Prieto Alfred C. O. Vertegaal Meindert Lamers Sébastien Huet Haico van Attikum Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining
description	Classical non-homologous end-joining (cNHEJ) is the dominant pathway used by human cells to repair DNA double-strand breaks (DSBs) and maintain genome stability. Here the authors show that PARP1-driven chromatin expansion allows the recruitment of ZNF384, which in turn recruits Ku70/Ku80 to facilitate cNHEJ.
format	article
author	Jenny Kaur Singh Rebecca Smith Magdalena B. Rother Anton J. L. de Groot Wouter W. Wiegant Kees Vreeken Ostiane D’Augustin Robbert Q. Kim Haibin Qian Przemek M. Krawczyk Román González-Prieto Alfred C. O. Vertegaal Meindert Lamers Sébastien Huet Haico van Attikum
author_facet	Jenny Kaur Singh Rebecca Smith Magdalena B. Rother Anton J. L. de Groot Wouter W. Wiegant Kees Vreeken Ostiane D’Augustin Robbert Q. Kim Haibin Qian Przemek M. Krawczyk Román González-Prieto Alfred C. O. Vertegaal Meindert Lamers Sébastien Huet Haico van Attikum
author_sort	Jenny Kaur Singh
title	Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining
title_short	Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining
title_full	Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining
title_fullStr	Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining
title_full_unstemmed	Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining
title_sort	zinc finger protein znf384 is an adaptor of ku to dna during classical non-homologous end-joining
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81eb6422ad4941fe875820f223a85fd7
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Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining

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