Evolution of high-level resistance during low-level antibiotic exposure

Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.

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Autores principales: Erik Wistrand-Yuen, Michael Knopp, Karin Hjort, Sanna Koskiniemi, Otto G. Berg, Dan I. Andersson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/81f65f64c61b4ccbb903415fc281cf6f
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