Evolution of high-level resistance during low-level antibiotic exposure

Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.

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Bibliographic Details
Main Authors:	Erik Wistrand-Yuen, Michael Knopp, Karin Hjort, Sanna Koskiniemi, Otto G. Berg, Dan I. Andersson
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/81f65f64c61b4ccbb903415fc281cf6f
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id	oai:doaj.org-article:81f65f64c61b4ccbb903415fc281cf6f
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spelling	oai:doaj.org-article:81f65f64c61b4ccbb903415fc281cf6f2021-12-02T16:49:56ZEvolution of high-level resistance during low-level antibiotic exposure10.1038/s41467-018-04059-12041-1723https://doaj.org/article/81f65f64c61b4ccbb903415fc281cf6f2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04059-1https://doaj.org/toc/2041-1723Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.Erik Wistrand-YuenMichael KnoppKarin HjortSanna KoskiniemiOtto G. BergDan I. AnderssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson Evolution of high-level resistance during low-level antibiotic exposure
description	Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.
format	article
author	Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson
author_facet	Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson
author_sort	Erik Wistrand-Yuen
title	Evolution of high-level resistance during low-level antibiotic exposure
title_short	Evolution of high-level resistance during low-level antibiotic exposure
title_full	Evolution of high-level resistance during low-level antibiotic exposure
title_fullStr	Evolution of high-level resistance during low-level antibiotic exposure
title_full_unstemmed	Evolution of high-level resistance during low-level antibiotic exposure
title_sort	evolution of high-level resistance during low-level antibiotic exposure
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/81f65f64c61b4ccbb903415fc281cf6f
work_keys_str_mv	AT erikwistrandyuen evolutionofhighlevelresistanceduringlowlevelantibioticexposure AT michaelknopp evolutionofhighlevelresistanceduringlowlevelantibioticexposure AT karinhjort evolutionofhighlevelresistanceduringlowlevelantibioticexposure AT sannakoskiniemi evolutionofhighlevelresistanceduringlowlevelantibioticexposure AT ottogberg evolutionofhighlevelresistanceduringlowlevelantibioticexposure AT daniandersson evolutionofhighlevelresistanceduringlowlevelantibioticexposure
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Evolution of high-level resistance during low-level antibiotic exposure

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