Evolution of high-level resistance during low-level antibiotic exposure
Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.
Guardado en:
Autores principales: | Erik Wistrand-Yuen, Michael Knopp, Karin Hjort, Sanna Koskiniemi, Otto G. Berg, Dan I. Andersson |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/81f65f64c61b4ccbb903415fc281cf6f |
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