BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system.

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system.

BACE1 is a key enzyme for amyloid-β (Aβ) production, and an attractive therapeutic target in Alzheimer's disease (AD). Here we report that BACE1 inhibitors have distinct effects on neuronal Aβ metabolism, inducing a unique pattern of secreted Aβ peptides, analyzed in cell media from amyloid pre...

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Main Authors: Niklas Mattsson, Lawrence Rajendran, Henrik Zetterberg, Mikael Gustavsson, Ulf Andreasson, Maria Olsson, Gunnar Brinkmalm, Johan Lundkvist, Laura H Jacobson, Ludovic Perrot, Ulf Neumann, Herman Borghys, Marc Mercken, Deborah Dhuyvetter, Fredrik Jeppsson, Kaj Blennow, Erik Portelius
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/820b53e8ca3c4c7fb2421581da40bd31
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https://doaj.org/article/820b53e8ca3c4c7fb2421581da40bd31

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