Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

The understanding of the changes regulating gene expression relevant for the emergence of the human brain and its susceptibility to disease is limited. Here, the authors identified a set of regulatory elements that evolved in hominins affecting oligodendrocyte function, and link these to autism.

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Autores principales: Bas Castelijns, Mirna L. Baak, Ilia S. Timpanaro, Caroline R. M. Wiggers, Marit W. Vermunt, Peng Shang, Ivanela Kondova, Geert Geeven, Valerio Bianchi, Wouter de Laat, Niels Geijsen, Menno P. Creyghton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/82266434e4204259b6a7fa449dc212bd
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