Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

The understanding of the changes regulating gene expression relevant for the emergence of the human brain and its susceptibility to disease is limited. Here, the authors identified a set of regulatory elements that evolved in hominins affecting oligodendrocyte function, and link these to autism.

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Autores principales:	Bas Castelijns, Mirna L. Baak, Ilia S. Timpanaro, Caroline R. M. Wiggers, Marit W. Vermunt, Peng Shang, Ivanela Kondova, Geert Geeven, Valerio Bianchi, Wouter de Laat, Niels Geijsen, Menno P. Creyghton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82266434e4204259b6a7fa449dc212bd
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spelling	oai:doaj.org-article:82266434e4204259b6a7fa449dc212bd2021-12-02T17:31:40ZHominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients10.1038/s41467-019-14269-w2041-1723https://doaj.org/article/82266434e4204259b6a7fa449dc212bd2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14269-whttps://doaj.org/toc/2041-1723The understanding of the changes regulating gene expression relevant for the emergence of the human brain and its susceptibility to disease is limited. Here, the authors identified a set of regulatory elements that evolved in hominins affecting oligodendrocyte function, and link these to autism.Bas CastelijnsMirna L. BaakIlia S. TimpanaroCaroline R. M. WiggersMarit W. VermuntPeng ShangIvanela KondovaGeert GeevenValerio BianchiWouter de LaatNiels GeijsenMenno P. CreyghtonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bas Castelijns Mirna L. Baak Ilia S. Timpanaro Caroline R. M. Wiggers Marit W. Vermunt Peng Shang Ivanela Kondova Geert Geeven Valerio Bianchi Wouter de Laat Niels Geijsen Menno P. Creyghton Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
description	The understanding of the changes regulating gene expression relevant for the emergence of the human brain and its susceptibility to disease is limited. Here, the authors identified a set of regulatory elements that evolved in hominins affecting oligodendrocyte function, and link these to autism.
format	article
author	Bas Castelijns Mirna L. Baak Ilia S. Timpanaro Caroline R. M. Wiggers Marit W. Vermunt Peng Shang Ivanela Kondova Geert Geeven Valerio Bianchi Wouter de Laat Niels Geijsen Menno P. Creyghton
author_facet	Bas Castelijns Mirna L. Baak Ilia S. Timpanaro Caroline R. M. Wiggers Marit W. Vermunt Peng Shang Ivanela Kondova Geert Geeven Valerio Bianchi Wouter de Laat Niels Geijsen Menno P. Creyghton
author_sort	Bas Castelijns
title	Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
title_short	Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
title_full	Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
title_fullStr	Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
title_full_unstemmed	Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
title_sort	hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/82266434e4204259b6a7fa449dc212bd
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Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

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