Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer.

Breast cancer is a very heterogeneous disease, and ~30% of breast cancer patients succumb to metastasis, highlighting the need to understand the mechanisms of breast cancer progression in order to identify new molecular targets for treatment. Sphingosine kinase 1 (SK1) has been shown to be upregulat...

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Autores principales: Fabiola N Velazquez, Leiqing Zhang, Valentina Viscardi, Carolena Trocchia, Yusuf A Hannun, Lina M Obeid, Ashley J Snider
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/82365634bb0c4285b6c0179117fab065
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