Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer.
Breast cancer is a very heterogeneous disease, and ~30% of breast cancer patients succumb to metastasis, highlighting the need to understand the mechanisms of breast cancer progression in order to identify new molecular targets for treatment. Sphingosine kinase 1 (SK1) has been shown to be upregulat...
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Autores principales: | Fabiola N Velazquez, Leiqing Zhang, Valentina Viscardi, Carolena Trocchia, Yusuf A Hannun, Lina M Obeid, Ashley J Snider |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/82365634bb0c4285b6c0179117fab065 |
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