Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity

Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity

Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.

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Bibliographic Details
Main Authors: Rhodora C. Calizo, Smiti Bhattacharya, J. G. Coen van Hasselt, Chengguo Wei, Jenny S. Wong, Robert J. Wiener, Xuhua Ge, Nicholas J. Wong, Jia-Jye Lee, Christina M. Cuttitta, Gomathi Jayaraman, Vivienne H. Au, William Janssen, Tong Liu, Hong Li, Fadi Salem, Edgar A. Jaimes, Barbara Murphy, Kirk N. Campbell, Evren U. Azeloglu
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/8269d038cbb047b6863d44efd06fc28f
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Internet

https://doaj.org/article/8269d038cbb047b6863d44efd06fc28f

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