Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.
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Nature Portfolio
2019
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oai:doaj.org-article:8269d038cbb047b6863d44efd06fc28f2021-12-02T14:39:20ZDisruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity10.1038/s41467-019-09936-x2041-1723https://doaj.org/article/8269d038cbb047b6863d44efd06fc28f2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09936-xhttps://doaj.org/toc/2041-1723Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.Rhodora C. CalizoSmiti BhattacharyaJ. G. Coen van HasseltChengguo WeiJenny S. WongRobert J. WienerXuhua GeNicholas J. WongJia-Jye LeeChristina M. CuttittaGomathi JayaramanVivienne H. AuWilliam JanssenTong LiuHong LiFadi SalemEdgar A. JaimesBarbara MurphyKirk N. CampbellEvren U. AzelogluNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Rhodora C. Calizo Smiti Bhattacharya J. G. Coen van Hasselt Chengguo Wei Jenny S. Wong Robert J. Wiener Xuhua Ge Nicholas J. Wong Jia-Jye Lee Christina M. Cuttitta Gomathi Jayaraman Vivienne H. Au William Janssen Tong Liu Hong Li Fadi Salem Edgar A. Jaimes Barbara Murphy Kirk N. Campbell Evren U. Azeloglu Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| description |
Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes. |
| format |
article |
| author |
Rhodora C. Calizo Smiti Bhattacharya J. G. Coen van Hasselt Chengguo Wei Jenny S. Wong Robert J. Wiener Xuhua Ge Nicholas J. Wong Jia-Jye Lee Christina M. Cuttitta Gomathi Jayaraman Vivienne H. Au William Janssen Tong Liu Hong Li Fadi Salem Edgar A. Jaimes Barbara Murphy Kirk N. Campbell Evren U. Azeloglu |
| author_facet |
Rhodora C. Calizo Smiti Bhattacharya J. G. Coen van Hasselt Chengguo Wei Jenny S. Wong Robert J. Wiener Xuhua Ge Nicholas J. Wong Jia-Jye Lee Christina M. Cuttitta Gomathi Jayaraman Vivienne H. Au William Janssen Tong Liu Hong Li Fadi Salem Edgar A. Jaimes Barbara Murphy Kirk N. Campbell Evren U. Azeloglu |
| author_sort |
Rhodora C. Calizo |
| title |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_short |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_full |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_fullStr |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_full_unstemmed |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_sort |
disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/8269d038cbb047b6863d44efd06fc28f |
| work_keys_str_mv |
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| _version_ |
1718390665575923712 |