Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2019
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/8269d038cbb047b6863d44efd06fc28f |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| id |
oai:doaj.org-article:8269d038cbb047b6863d44efd06fc28f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8269d038cbb047b6863d44efd06fc28f2021-12-02T14:39:20ZDisruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity10.1038/s41467-019-09936-x2041-1723https://doaj.org/article/8269d038cbb047b6863d44efd06fc28f2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09936-xhttps://doaj.org/toc/2041-1723Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.Rhodora C. CalizoSmiti BhattacharyaJ. G. Coen van HasseltChengguo WeiJenny S. WongRobert J. WienerXuhua GeNicholas J. WongJia-Jye LeeChristina M. CuttittaGomathi JayaramanVivienne H. AuWilliam JanssenTong LiuHong LiFadi SalemEdgar A. JaimesBarbara MurphyKirk N. CampbellEvren U. AzelogluNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Rhodora C. Calizo Smiti Bhattacharya J. G. Coen van Hasselt Chengguo Wei Jenny S. Wong Robert J. Wiener Xuhua Ge Nicholas J. Wong Jia-Jye Lee Christina M. Cuttitta Gomathi Jayaraman Vivienne H. Au William Janssen Tong Liu Hong Li Fadi Salem Edgar A. Jaimes Barbara Murphy Kirk N. Campbell Evren U. Azeloglu Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| description |
Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes. |
| format |
article |
| author |
Rhodora C. Calizo Smiti Bhattacharya J. G. Coen van Hasselt Chengguo Wei Jenny S. Wong Robert J. Wiener Xuhua Ge Nicholas J. Wong Jia-Jye Lee Christina M. Cuttitta Gomathi Jayaraman Vivienne H. Au William Janssen Tong Liu Hong Li Fadi Salem Edgar A. Jaimes Barbara Murphy Kirk N. Campbell Evren U. Azeloglu |
| author_facet |
Rhodora C. Calizo Smiti Bhattacharya J. G. Coen van Hasselt Chengguo Wei Jenny S. Wong Robert J. Wiener Xuhua Ge Nicholas J. Wong Jia-Jye Lee Christina M. Cuttitta Gomathi Jayaraman Vivienne H. Au William Janssen Tong Liu Hong Li Fadi Salem Edgar A. Jaimes Barbara Murphy Kirk N. Campbell Evren U. Azeloglu |
| author_sort |
Rhodora C. Calizo |
| title |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_short |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_full |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_fullStr |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_full_unstemmed |
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| title_sort |
disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/8269d038cbb047b6863d44efd06fc28f |
| work_keys_str_mv |
AT rhodoraccalizo disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT smitibhattacharya disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT jgcoenvanhasselt disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT chengguowei disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT jennyswong disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT robertjwiener disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT xuhuage disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT nicholasjwong disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT jiajyelee disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT christinamcuttitta disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT gomathijayaraman disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT viviennehau disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT williamjanssen disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT tongliu disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT hongli disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT fadisalem disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT edgarajaimes disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT barbaramurphy disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT kirkncampbell disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity AT evrenuazeloglu disruptionofpodocytecytoskeletalbiomechanicsbydasatinibleadstonephrotoxicity |
| _version_ |
1718390665575923712 |