Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals

Genetic elements that control inflammatory gene expression are not fully elucidated. Here the authors conduct a multi-species analysis of chromatin landscape and NF-κB binding in response to the proinflammatory cytokine TNFα, finding that conserved NF-κB bound regions are linked to enhancer activity...

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Autores principales:	Azad Alizada, Nadiya Khyzha, Liangxi Wang, Lina Antounians, Xiaoting Chen, Melvin Khor, Minggao Liang, Kumaragurubaran Rathnakumar, Matthew T. Weirauch, Alejandra Medina-Rivera, Jason E. Fish, Michael D. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8269d7eb565b4f2d87f9bcd58c9accef
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spelling	oai:doaj.org-article:8269d7eb565b4f2d87f9bcd58c9accef2021-12-02T14:16:40ZConserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals10.1038/s41467-020-20765-12041-1723https://doaj.org/article/8269d7eb565b4f2d87f9bcd58c9accef2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20765-1https://doaj.org/toc/2041-1723Genetic elements that control inflammatory gene expression are not fully elucidated. Here the authors conduct a multi-species analysis of chromatin landscape and NF-κB binding in response to the proinflammatory cytokine TNFα, finding that conserved NF-κB bound regions are linked to enhancer activity and disease.Azad AlizadaNadiya KhyzhaLiangxi WangLina AntouniansXiaoting ChenMelvin KhorMinggao LiangKumaragurubaran RathnakumarMatthew T. WeirauchAlejandra Medina-RiveraJason E. FishMichael D. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Azad Alizada Nadiya Khyzha Liangxi Wang Lina Antounians Xiaoting Chen Melvin Khor Minggao Liang Kumaragurubaran Rathnakumar Matthew T. Weirauch Alejandra Medina-Rivera Jason E. Fish Michael D. Wilson Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
description	Genetic elements that control inflammatory gene expression are not fully elucidated. Here the authors conduct a multi-species analysis of chromatin landscape and NF-κB binding in response to the proinflammatory cytokine TNFα, finding that conserved NF-κB bound regions are linked to enhancer activity and disease.
format	article
author	Azad Alizada Nadiya Khyzha Liangxi Wang Lina Antounians Xiaoting Chen Melvin Khor Minggao Liang Kumaragurubaran Rathnakumar Matthew T. Weirauch Alejandra Medina-Rivera Jason E. Fish Michael D. Wilson
author_facet	Azad Alizada Nadiya Khyzha Liangxi Wang Lina Antounians Xiaoting Chen Melvin Khor Minggao Liang Kumaragurubaran Rathnakumar Matthew T. Weirauch Alejandra Medina-Rivera Jason E. Fish Michael D. Wilson
author_sort	Azad Alizada
title	Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
title_short	Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
title_full	Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
title_fullStr	Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
title_full_unstemmed	Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
title_sort	conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8269d7eb565b4f2d87f9bcd58c9accef
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Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals

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