Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding

The decarboxylate enzyme Fdc1 requires a prenylated flavin mononucleotide co-factor for activity. Here, the authors use a variety of mass spectrometric techniques to observe the structural changes in this protein in response to co-factor binding.

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Autores principales:	Rebecca Beveridge, Lukasz G. Migas, Karl A. P. Payne, Nigel S. Scrutton, David Leys, Perdita E. Barran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82700913d4364c30a94137e5cd1da852
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spelling	oai:doaj.org-article:82700913d4364c30a94137e5cd1da8522021-12-02T17:31:18ZMass spectrometry locates local and allosteric conformational changes that occur on cofactor binding10.1038/ncomms121632041-1723https://doaj.org/article/82700913d4364c30a94137e5cd1da8522016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12163https://doaj.org/toc/2041-1723The decarboxylate enzyme Fdc1 requires a prenylated flavin mononucleotide co-factor for activity. Here, the authors use a variety of mass spectrometric techniques to observe the structural changes in this protein in response to co-factor binding.Rebecca BeveridgeLukasz G. MigasKarl A. P. PayneNigel S. ScruttonDavid LeysPerdita E. BarranNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Beveridge Lukasz G. Migas Karl A. P. Payne Nigel S. Scrutton David Leys Perdita E. Barran Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
description	The decarboxylate enzyme Fdc1 requires a prenylated flavin mononucleotide co-factor for activity. Here, the authors use a variety of mass spectrometric techniques to observe the structural changes in this protein in response to co-factor binding.
format	article
author	Rebecca Beveridge Lukasz G. Migas Karl A. P. Payne Nigel S. Scrutton David Leys Perdita E. Barran
author_facet	Rebecca Beveridge Lukasz G. Migas Karl A. P. Payne Nigel S. Scrutton David Leys Perdita E. Barran
author_sort	Rebecca Beveridge
title	Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
title_short	Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
title_full	Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
title_fullStr	Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
title_full_unstemmed	Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
title_sort	mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/82700913d4364c30a94137e5cd1da852
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Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding

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