Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

Voltage-gated Ca2+ channels are thought to contribute to neurodegeneration of dopaminergic neurons. Here the authors find that the R-type channel Cav2.3 in substantia nigra dopaminergic neurons may contribute to neurodegeneration in a model of Parkinson’s disease, in contrast to the neuroprotective...

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Autores principales: Julia Benkert, Simon Hess, Shoumik Roy, Dayne Beccano-Kelly, Nicole Wiederspohn, Johanna Duda, Carsten Simons, Komal Patil, Aisylu Gaifullina, Nadja Mannal, Elena Dragicevic, Desirée Spaich, Sonja Müller, Julia Nemeth, Helene Hollmann, Nora Deuter, Yassine Mousba, Christian Kubisch, Christina Poetschke, Joerg Striessnig, Olaf Pongs, Toni Schneider, Richard Wade-Martins, Sandip Patel, Rosanna Parlato, Tobias Frank, Peter Kloppenburg, Birgit Liss
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/8271fb3221094175818e53f6966e1e51
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spelling oai:doaj.org-article:8271fb3221094175818e53f6966e1e512021-12-02T15:35:35ZCav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease10.1038/s41467-019-12834-x2041-1723https://doaj.org/article/8271fb3221094175818e53f6966e1e512019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12834-xhttps://doaj.org/toc/2041-1723Voltage-gated Ca2+ channels are thought to contribute to neurodegeneration of dopaminergic neurons. Here the authors find that the R-type channel Cav2.3 in substantia nigra dopaminergic neurons may contribute to neurodegeneration in a model of Parkinson’s disease, in contrast to the neuroprotective action of the neuronal Ca2+ sensor NCS-1.Julia BenkertSimon HessShoumik RoyDayne Beccano-KellyNicole WiederspohnJohanna DudaCarsten SimonsKomal PatilAisylu GaifullinaNadja MannalElena DragicevicDesirée SpaichSonja MüllerJulia NemethHelene HollmannNora DeuterYassine MousbaChristian KubischChristina PoetschkeJoerg StriessnigOlaf PongsToni SchneiderRichard Wade-MartinsSandip PatelRosanna ParlatoTobias FrankPeter KloppenburgBirgit LissNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julia Benkert
Simon Hess
Shoumik Roy
Dayne Beccano-Kelly
Nicole Wiederspohn
Johanna Duda
Carsten Simons
Komal Patil
Aisylu Gaifullina
Nadja Mannal
Elena Dragicevic
Desirée Spaich
Sonja Müller
Julia Nemeth
Helene Hollmann
Nora Deuter
Yassine Mousba
Christian Kubisch
Christina Poetschke
Joerg Striessnig
Olaf Pongs
Toni Schneider
Richard Wade-Martins
Sandip Patel
Rosanna Parlato
Tobias Frank
Peter Kloppenburg
Birgit Liss
Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
description Voltage-gated Ca2+ channels are thought to contribute to neurodegeneration of dopaminergic neurons. Here the authors find that the R-type channel Cav2.3 in substantia nigra dopaminergic neurons may contribute to neurodegeneration in a model of Parkinson’s disease, in contrast to the neuroprotective action of the neuronal Ca2+ sensor NCS-1.
format article
author Julia Benkert
Simon Hess
Shoumik Roy
Dayne Beccano-Kelly
Nicole Wiederspohn
Johanna Duda
Carsten Simons
Komal Patil
Aisylu Gaifullina
Nadja Mannal
Elena Dragicevic
Desirée Spaich
Sonja Müller
Julia Nemeth
Helene Hollmann
Nora Deuter
Yassine Mousba
Christian Kubisch
Christina Poetschke
Joerg Striessnig
Olaf Pongs
Toni Schneider
Richard Wade-Martins
Sandip Patel
Rosanna Parlato
Tobias Frank
Peter Kloppenburg
Birgit Liss
author_facet Julia Benkert
Simon Hess
Shoumik Roy
Dayne Beccano-Kelly
Nicole Wiederspohn
Johanna Duda
Carsten Simons
Komal Patil
Aisylu Gaifullina
Nadja Mannal
Elena Dragicevic
Desirée Spaich
Sonja Müller
Julia Nemeth
Helene Hollmann
Nora Deuter
Yassine Mousba
Christian Kubisch
Christina Poetschke
Joerg Striessnig
Olaf Pongs
Toni Schneider
Richard Wade-Martins
Sandip Patel
Rosanna Parlato
Tobias Frank
Peter Kloppenburg
Birgit Liss
author_sort Julia Benkert
title Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
title_short Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
title_full Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
title_fullStr Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
title_full_unstemmed Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
title_sort cav2.3 channels contribute to dopaminergic neuron loss in a model of parkinson’s disease
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/8271fb3221094175818e53f6966e1e51
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