Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor

Centralspindlin consists of dimeric kinesin-6 and dimeric RacGAP, and is involved in the organization of anaphase midzone microtubules. Here, the authors show that the RacGAP is needed for motor activity at the plus-end of microtubules, but not for the bundling activity associated with kinesin-6.

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Detalles Bibliográficos
Autores principales:	Li Tao, Barbara Fasulo, Brandt Warecki, William Sullivan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82744fb30fab4a969fdb2f06d28fb301
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id	oai:doaj.org-article:82744fb30fab4a969fdb2f06d28fb301
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spelling	oai:doaj.org-article:82744fb30fab4a969fdb2f06d28fb3012021-12-02T15:34:59ZTum/RacGAP functions as a switch activating the Pav/kinesin-6 motor10.1038/ncomms111822041-1723https://doaj.org/article/82744fb30fab4a969fdb2f06d28fb3012016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11182https://doaj.org/toc/2041-1723Centralspindlin consists of dimeric kinesin-6 and dimeric RacGAP, and is involved in the organization of anaphase midzone microtubules. Here, the authors show that the RacGAP is needed for motor activity at the plus-end of microtubules, but not for the bundling activity associated with kinesin-6.Li TaoBarbara FasuloBrandt WareckiWilliam SullivanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Tao Barbara Fasulo Brandt Warecki William Sullivan Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor
description	Centralspindlin consists of dimeric kinesin-6 and dimeric RacGAP, and is involved in the organization of anaphase midzone microtubules. Here, the authors show that the RacGAP is needed for motor activity at the plus-end of microtubules, but not for the bundling activity associated with kinesin-6.
format	article
author	Li Tao Barbara Fasulo Brandt Warecki William Sullivan
author_facet	Li Tao Barbara Fasulo Brandt Warecki William Sullivan
author_sort	Li Tao
title	Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor
title_short	Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor
title_full	Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor
title_fullStr	Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor
title_full_unstemmed	Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor
title_sort	tum/racgap functions as a switch activating the pav/kinesin-6 motor
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/82744fb30fab4a969fdb2f06d28fb301
work_keys_str_mv	AT litao tumracgapfunctionsasaswitchactivatingthepavkinesin6motor AT barbarafasulo tumracgapfunctionsasaswitchactivatingthepavkinesin6motor AT brandtwarecki tumracgapfunctionsasaswitchactivatingthepavkinesin6motor AT williamsullivan tumracgapfunctionsasaswitchactivatingthepavkinesin6motor
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Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor

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