Evolution of new regulatory functions on biophysically realistic fitness landscapes

Gene networks evolve by transcription factor (TF) duplication and divergence of their binding site specificities, but little is known about the global constraints at play. Here, the authors study the coevolution of TFs and binding sites using a biophysical-evolutionary approach, and show that the em...

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Main Authors:	Tamar Friedlander, Roshan Prizak, Nicholas H. Barton, Gašper Tkačik
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/82b95e6e068b446b81e274b59c7a0d9c
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id	oai:doaj.org-article:82b95e6e068b446b81e274b59c7a0d9c
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spelling	oai:doaj.org-article:82b95e6e068b446b81e274b59c7a0d9c2021-12-02T13:57:45ZEvolution of new regulatory functions on biophysically realistic fitness landscapes10.1038/s41467-017-00238-82041-1723https://doaj.org/article/82b95e6e068b446b81e274b59c7a0d9c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00238-8https://doaj.org/toc/2041-1723Gene networks evolve by transcription factor (TF) duplication and divergence of their binding site specificities, but little is known about the global constraints at play. Here, the authors study the coevolution of TFs and binding sites using a biophysical-evolutionary approach, and show that the emerging complex fitness landscapes strongly influence regulatory evolution with a role for crosstalk.Tamar FriedlanderRoshan PrizakNicholas H. BartonGašper TkačikNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamar Friedlander Roshan Prizak Nicholas H. Barton Gašper Tkačik Evolution of new regulatory functions on biophysically realistic fitness landscapes
description	Gene networks evolve by transcription factor (TF) duplication and divergence of their binding site specificities, but little is known about the global constraints at play. Here, the authors study the coevolution of TFs and binding sites using a biophysical-evolutionary approach, and show that the emerging complex fitness landscapes strongly influence regulatory evolution with a role for crosstalk.
format	article
author	Tamar Friedlander Roshan Prizak Nicholas H. Barton Gašper Tkačik
author_facet	Tamar Friedlander Roshan Prizak Nicholas H. Barton Gašper Tkačik
author_sort	Tamar Friedlander
title	Evolution of new regulatory functions on biophysically realistic fitness landscapes
title_short	Evolution of new regulatory functions on biophysically realistic fitness landscapes
title_full	Evolution of new regulatory functions on biophysically realistic fitness landscapes
title_fullStr	Evolution of new regulatory functions on biophysically realistic fitness landscapes
title_full_unstemmed	Evolution of new regulatory functions on biophysically realistic fitness landscapes
title_sort	evolution of new regulatory functions on biophysically realistic fitness landscapes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/82b95e6e068b446b81e274b59c7a0d9c
work_keys_str_mv	AT tamarfriedlander evolutionofnewregulatoryfunctionsonbiophysicallyrealisticfitnesslandscapes AT roshanprizak evolutionofnewregulatoryfunctionsonbiophysicallyrealisticfitnesslandscapes AT nicholashbarton evolutionofnewregulatoryfunctionsonbiophysicallyrealisticfitnesslandscapes AT gaspertkacik evolutionofnewregulatoryfunctionsonbiophysicallyrealisticfitnesslandscapes
_version_	1718392270413103104

Evolution of new regulatory functions on biophysically realistic fitness landscapes

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