Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.

Hantaviruses are among the most important zoonotic pathogens of humans and the subject of heightened global attention. Despite the importance of hantaviruses for public health, there is no consensus on their evolutionary history and especially the frequency of virus-host co-divergence versus cross-s...

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Autores principales:	Wen-Ping Guo, Xian-Dan Lin, Wen Wang, Jun-Hua Tian, Mei-Li Cong, Hai-Lin Zhang, Miao-Ruo Wang, Run-Hong Zhou, Jian-Bo Wang, Ming-Hui Li, Jianguo Xu, Edward C Holmes, Yong-Zhen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/82f090d935a44d3e99eaa7bddc733740
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spelling	oai:doaj.org-article:82f090d935a44d3e99eaa7bddc7337402021-11-18T06:06:04ZPhylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.1553-73661553-737410.1371/journal.ppat.1003159https://doaj.org/article/82f090d935a44d3e99eaa7bddc7337402013-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23408889/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Hantaviruses are among the most important zoonotic pathogens of humans and the subject of heightened global attention. Despite the importance of hantaviruses for public health, there is no consensus on their evolutionary history and especially the frequency of virus-host co-divergence versus cross-species virus transmission. Documenting the extent of hantavirus biodiversity, and particularly their range of mammalian hosts, is critical to resolving this issue. Here, we describe four novel hantaviruses (Huangpi virus, Lianghe virus, Longquan virus, and Yakeshi virus) sampled from bats and shrews in China, and which are distinct from other known hantaviruses. Huangpi virus was found in Pipistrellus abramus, Lianghe virus in Anourosorex squamipes, Longquan virus in Rhinolophus affinis, Rhinolophus sinicus, and Rhinolophus monoceros, and Yakeshi virus in Sorex isodon, respectively. A phylogenetic analysis of the available diversity of hantaviruses reveals the existence of four phylogroups that infect a range of mammalian hosts, as well as the occurrence of ancient reassortment events between the phylogroups. Notably, the phylogenetic histories of the viruses are not always congruent with those of their hosts, suggesting that cross-species transmission has played a major role during hantavirus evolution and at all taxonomic levels, although we also noted some evidence for virus-host co-divergence. Our phylogenetic analysis also suggests that hantaviruses might have first appeared in Chiroptera (bats) or Soricomorpha (moles and shrews), before emerging in rodent species. Overall, these data indicate that bats are likely to be important natural reservoir hosts of hantaviruses.Wen-Ping GuoXian-Dan LinWen WangJun-Hua TianMei-Li CongHai-Lin ZhangMiao-Ruo WangRun-Hong ZhouJian-Bo WangMing-Hui LiJianguo XuEdward C HolmesYong-Zhen ZhangPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 2, p e1003159 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Wen-Ping Guo Xian-Dan Lin Wen Wang Jun-Hua Tian Mei-Li Cong Hai-Lin Zhang Miao-Ruo Wang Run-Hong Zhou Jian-Bo Wang Ming-Hui Li Jianguo Xu Edward C Holmes Yong-Zhen Zhang Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
description	Hantaviruses are among the most important zoonotic pathogens of humans and the subject of heightened global attention. Despite the importance of hantaviruses for public health, there is no consensus on their evolutionary history and especially the frequency of virus-host co-divergence versus cross-species virus transmission. Documenting the extent of hantavirus biodiversity, and particularly their range of mammalian hosts, is critical to resolving this issue. Here, we describe four novel hantaviruses (Huangpi virus, Lianghe virus, Longquan virus, and Yakeshi virus) sampled from bats and shrews in China, and which are distinct from other known hantaviruses. Huangpi virus was found in Pipistrellus abramus, Lianghe virus in Anourosorex squamipes, Longquan virus in Rhinolophus affinis, Rhinolophus sinicus, and Rhinolophus monoceros, and Yakeshi virus in Sorex isodon, respectively. A phylogenetic analysis of the available diversity of hantaviruses reveals the existence of four phylogroups that infect a range of mammalian hosts, as well as the occurrence of ancient reassortment events between the phylogroups. Notably, the phylogenetic histories of the viruses are not always congruent with those of their hosts, suggesting that cross-species transmission has played a major role during hantavirus evolution and at all taxonomic levels, although we also noted some evidence for virus-host co-divergence. Our phylogenetic analysis also suggests that hantaviruses might have first appeared in Chiroptera (bats) or Soricomorpha (moles and shrews), before emerging in rodent species. Overall, these data indicate that bats are likely to be important natural reservoir hosts of hantaviruses.
format	article
author	Wen-Ping Guo Xian-Dan Lin Wen Wang Jun-Hua Tian Mei-Li Cong Hai-Lin Zhang Miao-Ruo Wang Run-Hong Zhou Jian-Bo Wang Ming-Hui Li Jianguo Xu Edward C Holmes Yong-Zhen Zhang
author_facet	Wen-Ping Guo Xian-Dan Lin Wen Wang Jun-Hua Tian Mei-Li Cong Hai-Lin Zhang Miao-Ruo Wang Run-Hong Zhou Jian-Bo Wang Ming-Hui Li Jianguo Xu Edward C Holmes Yong-Zhen Zhang
author_sort	Wen-Ping Guo
title	Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
title_short	Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
title_full	Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
title_fullStr	Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
title_full_unstemmed	Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
title_sort	phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/82f090d935a44d3e99eaa7bddc733740
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Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.

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