Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage

Summary: The transition from a fasted to a fed state is associated with extensive transcriptional remodeling in hepatocytes facilitated by hormonal- and nutritional-regulated transcription factors. Here, we use a liver-specific glucocorticoid receptor (GR) knockout (L-GRKO) model to investigate the...

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Autores principales: Stine M. Præstholm, Catarina M. Correia, Victor E. Goitea, Majken S. Siersbæk, Mathilde Jørgensen, Jesper F. Havelund, Thomas Å. Pedersen, Nils J. Færgeman, Lars Grøntved
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/830a919b1e394d2a9c82955554f4eaec
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