Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea

Kucha is a rare variety of tea tree that produces the non-stimulatory theacrine instead of caffeine. Here the authors show that theacrine synthase from Kucha has N9-methyltransferase activity resulting from amino acid substitutions that explain substrate specificity and could potentially guide produ...

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Autores principales:	Yue-Hong Zhang, Yi-Fang Li, Yongjin Wang, Li Tan, Zhi-Qin Cao, Chao Xie, Guo Xie, Hai-Biao Gong, Wan-Yang Sun, Shu-Hua Ouyang, Wen-Jun Duan, Xiaoyun Lu, Ke Ding, Hiroshi Kurihara, Dan Hu, Zhi-Min Zhang, Ikuro Abe, Rong-Rong He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/831a1c58bac342408bfb2cded697fa4f
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spelling	oai:doaj.org-article:831a1c58bac342408bfb2cded697fa4f2021-12-02T17:32:12ZIdentification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea10.1038/s41467-020-15324-72041-1723https://doaj.org/article/831a1c58bac342408bfb2cded697fa4f2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15324-7https://doaj.org/toc/2041-1723Kucha is a rare variety of tea tree that produces the non-stimulatory theacrine instead of caffeine. Here the authors show that theacrine synthase from Kucha has N9-methyltransferase activity resulting from amino acid substitutions that explain substrate specificity and could potentially guide production of caffeine-free tea.Yue-Hong ZhangYi-Fang LiYongjin WangLi TanZhi-Qin CaoChao XieGuo XieHai-Biao GongWan-Yang SunShu-Hua OuyangWen-Jun DuanXiaoyun LuKe DingHiroshi KuriharaDan HuZhi-Min ZhangIkuro AbeRong-Rong HeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yue-Hong Zhang Yi-Fang Li Yongjin Wang Li Tan Zhi-Qin Cao Chao Xie Guo Xie Hai-Biao Gong Wan-Yang Sun Shu-Hua Ouyang Wen-Jun Duan Xiaoyun Lu Ke Ding Hiroshi Kurihara Dan Hu Zhi-Min Zhang Ikuro Abe Rong-Rong He Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
description	Kucha is a rare variety of tea tree that produces the non-stimulatory theacrine instead of caffeine. Here the authors show that theacrine synthase from Kucha has N9-methyltransferase activity resulting from amino acid substitutions that explain substrate specificity and could potentially guide production of caffeine-free tea.
format	article
author	Yue-Hong Zhang Yi-Fang Li Yongjin Wang Li Tan Zhi-Qin Cao Chao Xie Guo Xie Hai-Biao Gong Wan-Yang Sun Shu-Hua Ouyang Wen-Jun Duan Xiaoyun Lu Ke Ding Hiroshi Kurihara Dan Hu Zhi-Min Zhang Ikuro Abe Rong-Rong He
author_facet	Yue-Hong Zhang Yi-Fang Li Yongjin Wang Li Tan Zhi-Qin Cao Chao Xie Guo Xie Hai-Biao Gong Wan-Yang Sun Shu-Hua Ouyang Wen-Jun Duan Xiaoyun Lu Ke Ding Hiroshi Kurihara Dan Hu Zhi-Min Zhang Ikuro Abe Rong-Rong He
author_sort	Yue-Hong Zhang
title	Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
title_short	Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
title_full	Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
title_fullStr	Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
title_full_unstemmed	Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
title_sort	identification and characterization of n9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/831a1c58bac342408bfb2cded697fa4f
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Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea

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