A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

Oxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood. Here, we present evidence that a highly conserved host lipase, acyloxyacyl hydrolase (AOAH), can play a significant role in reducing the pro-inf...

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Auteurs principaux: Benkun Zou, Michael Goodwin, Danial Saleem, Wei Jiang, Jianguo Tang, Yiwei Chu, Robert S Munford, Mingfang Lu
Format: article
Langue:EN
Publié: eLife Sciences Publications Ltd 2021
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Accès en ligne:https://doaj.org/article/8336c58698cd4c66a2824f8ee4b95e13
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