NUDT2 initiates viral RNA degradation by removal of 5′-phosphates

RNA of some viruses is protected from degradation by a 5′ triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.

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Autores principales:	Beatrice T. Laudenbach, Karsten Krey, Quirin Emslander, Line Lykke Andersen, Alexander Reim, Pietro Scaturro, Sarah Mundigl, Christopher Dächert, Katrin Manske, Markus Moser, Janos Ludwig, Dirk Wohlleber, Andrea Kröger, Marco Binder, Andreas Pichlmair
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83808abd13804cb1901e95ef41afb37f
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spelling	oai:doaj.org-article:83808abd13804cb1901e95ef41afb37f2021-11-28T12:31:50ZNUDT2 initiates viral RNA degradation by removal of 5′-phosphates10.1038/s41467-021-27239-y2041-1723https://doaj.org/article/83808abd13804cb1901e95ef41afb37f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27239-yhttps://doaj.org/toc/2041-1723RNA of some viruses is protected from degradation by a 5′ triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.Beatrice T. LaudenbachKarsten KreyQuirin EmslanderLine Lykke AndersenAlexander ReimPietro ScaturroSarah MundiglChristopher DächertKatrin ManskeMarkus MoserJanos LudwigDirk WohlleberAndrea KrögerMarco BinderAndreas PichlmairNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Beatrice T. Laudenbach Karsten Krey Quirin Emslander Line Lykke Andersen Alexander Reim Pietro Scaturro Sarah Mundigl Christopher Dächert Katrin Manske Markus Moser Janos Ludwig Dirk Wohlleber Andrea Kröger Marco Binder Andreas Pichlmair NUDT2 initiates viral RNA degradation by removal of 5′-phosphates
description	RNA of some viruses is protected from degradation by a 5′ triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.
format	article
author	Beatrice T. Laudenbach Karsten Krey Quirin Emslander Line Lykke Andersen Alexander Reim Pietro Scaturro Sarah Mundigl Christopher Dächert Katrin Manske Markus Moser Janos Ludwig Dirk Wohlleber Andrea Kröger Marco Binder Andreas Pichlmair
author_facet	Beatrice T. Laudenbach Karsten Krey Quirin Emslander Line Lykke Andersen Alexander Reim Pietro Scaturro Sarah Mundigl Christopher Dächert Katrin Manske Markus Moser Janos Ludwig Dirk Wohlleber Andrea Kröger Marco Binder Andreas Pichlmair
author_sort	Beatrice T. Laudenbach
title	NUDT2 initiates viral RNA degradation by removal of 5′-phosphates
title_short	NUDT2 initiates viral RNA degradation by removal of 5′-phosphates
title_full	NUDT2 initiates viral RNA degradation by removal of 5′-phosphates
title_fullStr	NUDT2 initiates viral RNA degradation by removal of 5′-phosphates
title_full_unstemmed	NUDT2 initiates viral RNA degradation by removal of 5′-phosphates
title_sort	nudt2 initiates viral rna degradation by removal of 5′-phosphates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83808abd13804cb1901e95ef41afb37f
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NUDT2 initiates viral RNA degradation by removal of 5′-phosphates

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