Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2

Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2

ABSTRACT HLA-C-mediated antigen presentation induces the killing of human immunodeficiency virus (HIV)-infected CD4+ T cells by cytotoxic T lymphocytes (CTLs). To evade killing, many HIV-1 group M strains decrease HLA-C surface levels using their accessory protein Vpu. However, some HIV-1 group M is...

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Autores principales: Kristina Hopfensperger, Jonathan Richard, Christina M. Stürzel, Frederic Bibollet-Ruche, Richard Apps, Marie Leoz, Jean-Christophe Plantier, Beatrice H. Hahn, Andrés Finzi, Frank Kirchhoff, Daniel Sauter
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
HIV-1
HIV-2
SIV
HLA-C
Vpu
Vif
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/839388e6abb74760963d4aefd5626c6e
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https://doaj.org/article/839388e6abb74760963d4aefd5626c6e

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