Small genomic insertions form enhancers that misregulate oncogenes

Small genomic insertions form enhancers that misregulate oncogenes

Sequencing initiatives have detected multiple types of mutations in cancer. Here the authors, analysing enhancer-targeting sequence data, show that small insertions in transcriptional enhancers are frequently found near oncogenes, and demonstrate how one mutation deregulates expression of LMO2 in le...

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Autores principales: Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/83aabc930e7b4c009b32aff780ab64f2
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https://doaj.org/article/83aabc930e7b4c009b32aff780ab64f2

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