Small genomic insertions form enhancers that misregulate oncogenes

Sequencing initiatives have detected multiple types of mutations in cancer. Here the authors, analysing enhancer-targeting sequence data, show that small insertions in transcriptional enhancers are frequently found near oncogenes, and demonstrate how one mutation deregulates expression of LMO2 in le...

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Auteurs principaux:	Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/83aabc930e7b4c009b32aff780ab64f2
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spelling	oai:doaj.org-article:83aabc930e7b4c009b32aff780ab64f22021-12-02T17:06:06ZSmall genomic insertions form enhancers that misregulate oncogenes10.1038/ncomms143852041-1723https://doaj.org/article/83aabc930e7b4c009b32aff780ab64f22017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14385https://doaj.org/toc/2041-1723Sequencing initiatives have detected multiple types of mutations in cancer. Here the authors, analysing enhancer-targeting sequence data, show that small insertions in transcriptional enhancers are frequently found near oncogenes, and demonstrate how one mutation deregulates expression of LMO2 in leukemia cells.Brian J. AbrahamDenes HniszAbraham S. WeintraubNicholas KwiatkowskiCharles H. LiZhaodong LiNina Weichert-LeaheySunniyat RahmanYu LiuJulia EtchinBenshang LiShuhong ShenTong Ihn LeeJinghui ZhangA. Thomas LookMarc R. MansourRichard A. YoungNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brian J. Abraham Denes Hnisz Abraham S. Weintraub Nicholas Kwiatkowski Charles H. Li Zhaodong Li Nina Weichert-Leahey Sunniyat Rahman Yu Liu Julia Etchin Benshang Li Shuhong Shen Tong Ihn Lee Jinghui Zhang A. Thomas Look Marc R. Mansour Richard A. Young Small genomic insertions form enhancers that misregulate oncogenes
description	Sequencing initiatives have detected multiple types of mutations in cancer. Here the authors, analysing enhancer-targeting sequence data, show that small insertions in transcriptional enhancers are frequently found near oncogenes, and demonstrate how one mutation deregulates expression of LMO2 in leukemia cells.
format	article
author	Brian J. Abraham Denes Hnisz Abraham S. Weintraub Nicholas Kwiatkowski Charles H. Li Zhaodong Li Nina Weichert-Leahey Sunniyat Rahman Yu Liu Julia Etchin Benshang Li Shuhong Shen Tong Ihn Lee Jinghui Zhang A. Thomas Look Marc R. Mansour Richard A. Young
author_facet	Brian J. Abraham Denes Hnisz Abraham S. Weintraub Nicholas Kwiatkowski Charles H. Li Zhaodong Li Nina Weichert-Leahey Sunniyat Rahman Yu Liu Julia Etchin Benshang Li Shuhong Shen Tong Ihn Lee Jinghui Zhang A. Thomas Look Marc R. Mansour Richard A. Young
author_sort	Brian J. Abraham
title	Small genomic insertions form enhancers that misregulate oncogenes
title_short	Small genomic insertions form enhancers that misregulate oncogenes
title_full	Small genomic insertions form enhancers that misregulate oncogenes
title_fullStr	Small genomic insertions form enhancers that misregulate oncogenes
title_full_unstemmed	Small genomic insertions form enhancers that misregulate oncogenes
title_sort	small genomic insertions form enhancers that misregulate oncogenes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/83aabc930e7b4c009b32aff780ab64f2
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Small genomic insertions form enhancers that misregulate oncogenes

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