Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences

Large-scale sequencing efforts have uncovered a large number of secondary metabolic pathways, but the chemicals they synthesise remain unknown. Here the authors present PRISM 4, which predicts the chemical structures encoded by microbial genome sequences, including all classes of bacterial antibioti...

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Autores principales:	Michael A. Skinnider, Chad W. Johnston, Mathusan Gunabalasingam, Nishanth J. Merwin, Agata M. Kieliszek, Robyn J. MacLellan, Haoxin Li, Michael R. M. Ranieri, Andrew L. H. Webster, My P. T. Cao, Annabelle Pfeifle, Norman Spencer, Q. Huy To, Dan Peter Wallace, Chris A. Dejong, Nathan A. Magarvey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83e96992a8014b8c835cc9b340aa8822
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spelling	oai:doaj.org-article:83e96992a8014b8c835cc9b340aa88222021-12-02T15:39:26ZComprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences10.1038/s41467-020-19986-12041-1723https://doaj.org/article/83e96992a8014b8c835cc9b340aa88222020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19986-1https://doaj.org/toc/2041-1723Large-scale sequencing efforts have uncovered a large number of secondary metabolic pathways, but the chemicals they synthesise remain unknown. Here the authors present PRISM 4, which predicts the chemical structures encoded by microbial genome sequences, including all classes of bacterial antibiotics in clinical use.Michael A. SkinniderChad W. JohnstonMathusan GunabalasingamNishanth J. MerwinAgata M. KieliszekRobyn J. MacLellanHaoxin LiMichael R. M. RanieriAndrew L. H. WebsterMy P. T. CaoAnnabelle PfeifleNorman SpencerQ. Huy ToDan Peter WallaceChris A. DejongNathan A. MagarveyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael A. Skinnider Chad W. Johnston Mathusan Gunabalasingam Nishanth J. Merwin Agata M. Kieliszek Robyn J. MacLellan Haoxin Li Michael R. M. Ranieri Andrew L. H. Webster My P. T. Cao Annabelle Pfeifle Norman Spencer Q. Huy To Dan Peter Wallace Chris A. Dejong Nathan A. Magarvey Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
description	Large-scale sequencing efforts have uncovered a large number of secondary metabolic pathways, but the chemicals they synthesise remain unknown. Here the authors present PRISM 4, which predicts the chemical structures encoded by microbial genome sequences, including all classes of bacterial antibiotics in clinical use.
format	article
author	Michael A. Skinnider Chad W. Johnston Mathusan Gunabalasingam Nishanth J. Merwin Agata M. Kieliszek Robyn J. MacLellan Haoxin Li Michael R. M. Ranieri Andrew L. H. Webster My P. T. Cao Annabelle Pfeifle Norman Spencer Q. Huy To Dan Peter Wallace Chris A. Dejong Nathan A. Magarvey
author_facet	Michael A. Skinnider Chad W. Johnston Mathusan Gunabalasingam Nishanth J. Merwin Agata M. Kieliszek Robyn J. MacLellan Haoxin Li Michael R. M. Ranieri Andrew L. H. Webster My P. T. Cao Annabelle Pfeifle Norman Spencer Q. Huy To Dan Peter Wallace Chris A. Dejong Nathan A. Magarvey
author_sort	Michael A. Skinnider
title	Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
title_short	Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
title_full	Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
title_fullStr	Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
title_full_unstemmed	Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
title_sort	comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/83e96992a8014b8c835cc9b340aa8822
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Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences

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