EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity of PRC2 in germ cells in mice.

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Autores principales: Roberta Ragazzini, Raquel Pérez-Palacios, Irem H. Baymaz, Seynabou Diop, Katia Ancelin, Dina Zielinski, Audrey Michaud, Maëlle Givelet, Mate Borsos, Setareh Aflaki, Patricia Legoix, Pascal W. T. C. Jansen, Nicolas Servant, Maria-Elena Torres-Padilla, Deborah Bourc’his, Pierre Fouchet, Michiel Vermeulen, Raphaël Margueron
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
Q
Acceso en línea:https://doaj.org/article/840ba9a727064edb97ff673ade34b357
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https://doaj.org/article/840ba9a727064edb97ff673ade34b357

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