EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity of PRC2 in germ cells in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Roberta Ragazzini, Raquel Pérez-Palacios, Irem H. Baymaz, Seynabou Diop, Katia Ancelin, Dina Zielinski, Audrey Michaud, Maëlle Givelet, Mate Borsos, Setareh Aflaki, Patricia Legoix, Pascal W. T. C. Jansen, Nicolas Servant, Maria-Elena Torres-Padilla, Deborah Bourc’his, Pierre Fouchet, Michiel Vermeulen, Raphaël Margueron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/840ba9a727064edb97ff673ade34b357
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:840ba9a727064edb97ff673ade34b357
record_format	dspace
spelling	oai:doaj.org-article:840ba9a727064edb97ff673ade34b3572021-12-02T17:32:56ZEZHIP constrains Polycomb Repressive Complex 2 activity in germ cells10.1038/s41467-019-11800-x2041-1723https://doaj.org/article/840ba9a727064edb97ff673ade34b3572019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11800-xhttps://doaj.org/toc/2041-1723Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity of PRC2 in germ cells in mice.Roberta RagazziniRaquel Pérez-PalaciosIrem H. BaymazSeynabou DiopKatia AncelinDina ZielinskiAudrey MichaudMaëlle GiveletMate BorsosSetareh AflakiPatricia LegoixPascal W. T. C. JansenNicolas ServantMaria-Elena Torres-PadillaDeborah Bourc’hisPierre FouchetMichiel VermeulenRaphaël MargueronNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roberta Ragazzini Raquel Pérez-Palacios Irem H. Baymaz Seynabou Diop Katia Ancelin Dina Zielinski Audrey Michaud Maëlle Givelet Mate Borsos Setareh Aflaki Patricia Legoix Pascal W. T. C. Jansen Nicolas Servant Maria-Elena Torres-Padilla Deborah Bourc’his Pierre Fouchet Michiel Vermeulen Raphaël Margueron EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
description	Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity of PRC2 in germ cells in mice.
format	article
author	Roberta Ragazzini Raquel Pérez-Palacios Irem H. Baymaz Seynabou Diop Katia Ancelin Dina Zielinski Audrey Michaud Maëlle Givelet Mate Borsos Setareh Aflaki Patricia Legoix Pascal W. T. C. Jansen Nicolas Servant Maria-Elena Torres-Padilla Deborah Bourc’his Pierre Fouchet Michiel Vermeulen Raphaël Margueron
author_facet	Roberta Ragazzini Raquel Pérez-Palacios Irem H. Baymaz Seynabou Diop Katia Ancelin Dina Zielinski Audrey Michaud Maëlle Givelet Mate Borsos Setareh Aflaki Patricia Legoix Pascal W. T. C. Jansen Nicolas Servant Maria-Elena Torres-Padilla Deborah Bourc’his Pierre Fouchet Michiel Vermeulen Raphaël Margueron
author_sort	Roberta Ragazzini
title	EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
title_short	EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
title_full	EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
title_fullStr	EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
title_full_unstemmed	EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
title_sort	ezhip constrains polycomb repressive complex 2 activity in germ cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/840ba9a727064edb97ff673ade34b357
work_keys_str_mv	AT robertaragazzini ezhipconstrainspolycombrepressivecomplex2activityingermcells AT raquelperezpalacios ezhipconstrainspolycombrepressivecomplex2activityingermcells AT iremhbaymaz ezhipconstrainspolycombrepressivecomplex2activityingermcells AT seynaboudiop ezhipconstrainspolycombrepressivecomplex2activityingermcells AT katiaancelin ezhipconstrainspolycombrepressivecomplex2activityingermcells AT dinazielinski ezhipconstrainspolycombrepressivecomplex2activityingermcells AT audreymichaud ezhipconstrainspolycombrepressivecomplex2activityingermcells AT maellegivelet ezhipconstrainspolycombrepressivecomplex2activityingermcells AT mateborsos ezhipconstrainspolycombrepressivecomplex2activityingermcells AT setarehaflaki ezhipconstrainspolycombrepressivecomplex2activityingermcells AT patricialegoix ezhipconstrainspolycombrepressivecomplex2activityingermcells AT pascalwtcjansen ezhipconstrainspolycombrepressivecomplex2activityingermcells AT nicolasservant ezhipconstrainspolycombrepressivecomplex2activityingermcells AT mariaelenatorrespadilla ezhipconstrainspolycombrepressivecomplex2activityingermcells AT deborahbourchis ezhipconstrainspolycombrepressivecomplex2activityingermcells AT pierrefouchet ezhipconstrainspolycombrepressivecomplex2activityingermcells AT michielvermeulen ezhipconstrainspolycombrepressivecomplex2activityingermcells AT raphaelmargueron ezhipconstrainspolycombrepressivecomplex2activityingermcells
_version_	1718380132388831232

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Ejemplares similares