Common germline-somatic variant interactions in advanced urothelial cancer

Common germline-somatic variant interactions in advanced urothelial cancer

The role of germline variation in human cancers is not fully understood. Here, the authors define the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced urothelial cancer patients.

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Auteurs principaux: Aram Vosoughi, Tuo Zhang, Kyrillus S. Shohdy, Panagiotis J. Vlachostergios, David C. Wilkes, Bhavneet Bhinder, Scott T. Tagawa, David M. Nanus, Ana M. Molina, Himisha Beltran, Cora N. Sternberg, Samaneh Motanagh, Brian D. Robinson, Jenny Xiang, Xiao Fan, Wendy K. Chung, Mark A. Rubin, Olivier Elemento, Andrea Sboner, Juan Miguel Mosquera, Bishoy M. Faltas
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
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Accès en ligne:https://doaj.org/article/841aaee60ec54eb68cb48ba20fbccfd4
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Internet

https://doaj.org/article/841aaee60ec54eb68cb48ba20fbccfd4

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