Common germline-somatic variant interactions in advanced urothelial cancer

The role of germline variation in human cancers is not fully understood. Here, the authors define the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced urothelial cancer patients.

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Detalles Bibliográficos
Autores principales:	Aram Vosoughi, Tuo Zhang, Kyrillus S. Shohdy, Panagiotis J. Vlachostergios, David C. Wilkes, Bhavneet Bhinder, Scott T. Tagawa, David M. Nanus, Ana M. Molina, Himisha Beltran, Cora N. Sternberg, Samaneh Motanagh, Brian D. Robinson, Jenny Xiang, Xiao Fan, Wendy K. Chung, Mark A. Rubin, Olivier Elemento, Andrea Sboner, Juan Miguel Mosquera, Bishoy M. Faltas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/841aaee60ec54eb68cb48ba20fbccfd4
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spelling	oai:doaj.org-article:841aaee60ec54eb68cb48ba20fbccfd42021-12-02T16:49:43ZCommon germline-somatic variant interactions in advanced urothelial cancer10.1038/s41467-020-19971-82041-1723https://doaj.org/article/841aaee60ec54eb68cb48ba20fbccfd42020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19971-8https://doaj.org/toc/2041-1723The role of germline variation in human cancers is not fully understood. Here, the authors define the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced urothelial cancer patients.Aram VosoughiTuo ZhangKyrillus S. ShohdyPanagiotis J. VlachostergiosDavid C. WilkesBhavneet BhinderScott T. TagawaDavid M. NanusAna M. MolinaHimisha BeltranCora N. SternbergSamaneh MotanaghBrian D. RobinsonJenny XiangXiao FanWendy K. ChungMark A. RubinOlivier ElementoAndrea SbonerJuan Miguel MosqueraBishoy M. FaltasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aram Vosoughi Tuo Zhang Kyrillus S. Shohdy Panagiotis J. Vlachostergios David C. Wilkes Bhavneet Bhinder Scott T. Tagawa David M. Nanus Ana M. Molina Himisha Beltran Cora N. Sternberg Samaneh Motanagh Brian D. Robinson Jenny Xiang Xiao Fan Wendy K. Chung Mark A. Rubin Olivier Elemento Andrea Sboner Juan Miguel Mosquera Bishoy M. Faltas Common germline-somatic variant interactions in advanced urothelial cancer
description	The role of germline variation in human cancers is not fully understood. Here, the authors define the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced urothelial cancer patients.
format	article
author	Aram Vosoughi Tuo Zhang Kyrillus S. Shohdy Panagiotis J. Vlachostergios David C. Wilkes Bhavneet Bhinder Scott T. Tagawa David M. Nanus Ana M. Molina Himisha Beltran Cora N. Sternberg Samaneh Motanagh Brian D. Robinson Jenny Xiang Xiao Fan Wendy K. Chung Mark A. Rubin Olivier Elemento Andrea Sboner Juan Miguel Mosquera Bishoy M. Faltas
author_facet	Aram Vosoughi Tuo Zhang Kyrillus S. Shohdy Panagiotis J. Vlachostergios David C. Wilkes Bhavneet Bhinder Scott T. Tagawa David M. Nanus Ana M. Molina Himisha Beltran Cora N. Sternberg Samaneh Motanagh Brian D. Robinson Jenny Xiang Xiao Fan Wendy K. Chung Mark A. Rubin Olivier Elemento Andrea Sboner Juan Miguel Mosquera Bishoy M. Faltas
author_sort	Aram Vosoughi
title	Common germline-somatic variant interactions in advanced urothelial cancer
title_short	Common germline-somatic variant interactions in advanced urothelial cancer
title_full	Common germline-somatic variant interactions in advanced urothelial cancer
title_fullStr	Common germline-somatic variant interactions in advanced urothelial cancer
title_full_unstemmed	Common germline-somatic variant interactions in advanced urothelial cancer
title_sort	common germline-somatic variant interactions in advanced urothelial cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/841aaee60ec54eb68cb48ba20fbccfd4
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Common germline-somatic variant interactions in advanced urothelial cancer

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