Design principles of the paradoxical feedback between pancreatic alpha and beta cells

Abstract Mammalian glucose homeostasis is controlled by the antagonistic hormones insulin and glucagon, secreted by pancreatic beta and alpha cells respectively. These two cell types are adjacently located in the islets of Langerhans and affect each others’ secretions in a paradoxical manner: while...

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Bibliographic Details
Main Authors: Immacolata Garzilli, Shalev Itzkovitz
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
R
Q
Online Access:https://doaj.org/article/842b91bfe3374bf2a79a625849f3eb22
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