Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence.

Rationally and efficiently modifying the amino-acid sequence of proteins to control their ability to undergo liquid-liquid phase separation (LLPS) on demand is not only highly desirable, but can also help to elucidate which protein features are important for LLPS. Here, we propose a computational me...

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Autores principales: Simon M Lichtinger, Adiran Garaizar, Rosana Collepardo-Guevara, Aleks Reinhardt
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/8451791b5c80476b8177c2c6cc4e33b7
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