Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL

Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL

Abstract The ATP-binding cassette transporter TAPL translocates polypeptides from the cytosol into the lysosomal lumen. TAPL can be divided into two functional units: coreTAPL, active in ATP-dependent peptide translocation, and the N-terminal membrane spanning domain, TMD0, responsible for cellular...

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Autores principales: Christoph Bock, Frank Löhr, Franz Tumulka, Katrin Reichel, Julia Würz, Gerhard Hummer, Lars Schäfer, Robert Tampé, Benesh Joseph, Frank Bernhard, Volker Dötsch, Rupert Abele
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Paramagnetic Relaxation Enhancement (PRE)
Nuclear Overhauser Effects (NOEs)
Helical Transmembrane (TMHs)
Pulsed Electron-electron Double Resonance
Nanodiscs
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/848161c3458d4b778156d6e149516c9c
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https://doaj.org/article/848161c3458d4b778156d6e149516c9c

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