Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study

Psychiatric sequelae substantially contribute to the post-acute burden of disease associated with COVID-19, persisting months after clearance of the virus. Brain imaging shows white matter (WM) hypodensities/hyperintensities, and the involvement of grey matter (GM) in prefrontal, anterior cingulate...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesco Benedetti, Mariagrazia Palladini, Marco Paolini, Elisa Melloni, Benedetta Vai, Rebecca De Lorenzo, Roberto Furlan, Patrizia Rovere-Querini, Andrea Falini, Mario Gennaro Mazza
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 SARS-COV-2 Magnetic resonance imaging Depression Anxiety PTSD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/84a451ee42cf4d08b57461fce4aefc1b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:84a451ee42cf4d08b57461fce4aefc1b
record_format	dspace
spelling	oai:doaj.org-article:84a451ee42cf4d08b57461fce4aefc1b2021-11-10T04:41:36ZBrain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study2666-354610.1016/j.bbih.2021.100387https://doaj.org/article/84a451ee42cf4d08b57461fce4aefc1b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666354621001903https://doaj.org/toc/2666-3546Psychiatric sequelae substantially contribute to the post-acute burden of disease associated with COVID-19, persisting months after clearance of the virus. Brain imaging shows white matter (WM) hypodensities/hyperintensities, and the involvement of grey matter (GM) in prefrontal, anterior cingulate (ACC) and insular cortex after COVID, but little is known about brain correlates of persistent psychopathology.With a multimodal approach, we studied whole brain voxel-based morphometry, diffusion-tensor imaging, and resting-state connectivity, to correlate MRI measures with depression and post-traumatic distress (PTSD) in 42 COVID-19 survivors without brain lesions, at 90.59 ± 54.66 days after COVID. Systemic immune-inflammation index (SII) measured in the emergency department, which reflects the immune response and systemic inflammation based on peripheral lymphocyte, neutrophil, and platelet counts, predicted worse self-rated depression and PTSD, widespread lower diffusivity along the main axis of WM tracts, and abnormal functional connectivity (FC) among resting state networks. Self-rated depression and PTSD inversely correlated with GM volumes in ACC and insula, axial diffusivity, and associated with FC.We observed overlapping associations between severity of inflammation during acute COVID-19, brain structure and function, and severity of depression and post-traumatic distress in survivors, thus warranting interest for further study of brain correlates of the post-acute COVID-19 syndrome. Beyond COVID-19, these findings support the hypothesis that regional GM, WM microstructure, and FC could mediate the relationship between a medical illness and its psychopathological sequelae, and are in agreement with current perspectives on the brain structural and functional underpinnings of depressive psychopathology.Francesco BenedettiMariagrazia PalladiniMarco PaoliniElisa MelloniBenedetta VaiRebecca De LorenzoRoberto FurlanPatrizia Rovere-QueriniAndrea FaliniMario Gennaro MazzaElsevierarticleCOVID-19SARS-COV-2Magnetic resonance imagingDepressionAnxietyPTSDNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain, Behavior, & Immunity - Health, Vol 18, Iss , Pp 100387- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-COV-2 Magnetic resonance imaging Depression Anxiety PTSD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	COVID-19 SARS-COV-2 Magnetic resonance imaging Depression Anxiety PTSD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Francesco Benedetti Mariagrazia Palladini Marco Paolini Elisa Melloni Benedetta Vai Rebecca De Lorenzo Roberto Furlan Patrizia Rovere-Querini Andrea Falini Mario Gennaro Mazza Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study
description	Psychiatric sequelae substantially contribute to the post-acute burden of disease associated with COVID-19, persisting months after clearance of the virus. Brain imaging shows white matter (WM) hypodensities/hyperintensities, and the involvement of grey matter (GM) in prefrontal, anterior cingulate (ACC) and insular cortex after COVID, but little is known about brain correlates of persistent psychopathology.With a multimodal approach, we studied whole brain voxel-based morphometry, diffusion-tensor imaging, and resting-state connectivity, to correlate MRI measures with depression and post-traumatic distress (PTSD) in 42 COVID-19 survivors without brain lesions, at 90.59 ± 54.66 days after COVID. Systemic immune-inflammation index (SII) measured in the emergency department, which reflects the immune response and systemic inflammation based on peripheral lymphocyte, neutrophil, and platelet counts, predicted worse self-rated depression and PTSD, widespread lower diffusivity along the main axis of WM tracts, and abnormal functional connectivity (FC) among resting state networks. Self-rated depression and PTSD inversely correlated with GM volumes in ACC and insula, axial diffusivity, and associated with FC.We observed overlapping associations between severity of inflammation during acute COVID-19, brain structure and function, and severity of depression and post-traumatic distress in survivors, thus warranting interest for further study of brain correlates of the post-acute COVID-19 syndrome. Beyond COVID-19, these findings support the hypothesis that regional GM, WM microstructure, and FC could mediate the relationship between a medical illness and its psychopathological sequelae, and are in agreement with current perspectives on the brain structural and functional underpinnings of depressive psychopathology.
format	article
author	Francesco Benedetti Mariagrazia Palladini Marco Paolini Elisa Melloni Benedetta Vai Rebecca De Lorenzo Roberto Furlan Patrizia Rovere-Querini Andrea Falini Mario Gennaro Mazza
author_facet	Francesco Benedetti Mariagrazia Palladini Marco Paolini Elisa Melloni Benedetta Vai Rebecca De Lorenzo Roberto Furlan Patrizia Rovere-Querini Andrea Falini Mario Gennaro Mazza
author_sort	Francesco Benedetti
title	Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study
title_short	Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study
title_full	Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study
title_fullStr	Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study
title_full_unstemmed	Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study
title_sort	brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in covid-19 survivors: a multimodal magnetic resonance imaging study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/84a451ee42cf4d08b57461fce4aefc1b
work_keys_str_mv	AT francescobenedetti braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT mariagraziapalladini braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT marcopaolini braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT elisamelloni braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT benedettavai braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT rebeccadelorenzo braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT robertofurlan braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT patriziaroverequerini braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT andreafalini braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy AT mariogennaromazza braincorrelatesofdepressionposttraumaticdistressandinflammatorybiomarkersincovid19survivorsamultimodalmagneticresonanceimagingstudy
_version_	1718440573905403904

Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study

Ejemplares similares