Sequential activation of classic PKC and estrogen receptor α is involved in estradiol 17ß-D-glucuronide-induced cholestasis.

Sequential activation of classic PKC and estrogen receptor α is involved in estradiol 17ß-D-glucuronide-induced cholestasis.

<h4>Unlabelled</h4>Estradiol 17ß-D-glucuronide (E17G) induces acute cholestasis in rat with endocytic internalization of the canalicular transporters bile salt export pump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). Classical protein kinase C (cPKC) and PI3K pathways...

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Main Authors: Ismael R Barosso, Andrés E Zucchetti, Andrea C Boaglio, M Cecilia Larocca, Diego R Taborda, Marcelo G Luquita, Marcelo G Roma, Fernando A Crocenzi, Enrique J Sánchez Pozzi
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/84c3f8f9c4aa4c06b43872c5efbda6ac
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