Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson’s Disease

Parkinson’s disease is a neurodegenerative disorder with an inflammatory response as the core pathogenic mechanism. Previous human genetics findings support the view that the loss of TREM2 function will aggravate neurodegeneration, and TREM2 is one of the most highly expressed receptors in microglia...

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Auteurs principaux: Wei Huang, Qiankun Lv, Yunfei Xiao, Zhen Zhong, Binbin Hu, Si Yan, Yufang Yan, Junjun Zhang, Ting Shi, Lijuan Jiang, Wen Li, Guohui Lu
Format: article
Langue:EN
Publié: Frontiers Media S.A. 2021
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Accès en ligne:https://doaj.org/article/84cd87ef3cb84882adcbe9fa19f58905
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