An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitulate the key processes for antibody persistence in c...

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Autores principales:	Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84d23b07351d4847b7e49dca2fbb568c
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spelling	oai:doaj.org-article:84d23b07351d4847b7e49dca2fbb568c2021-12-02T16:58:19ZAn engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence10.1038/s41467-019-13108-22041-1723https://doaj.org/article/84d23b07351d4847b7e49dca2fbb568c2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13108-2https://doaj.org/toc/2041-1723Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitulate the key processes for antibody persistence in circulation.Chang-Han LeeTae Hyun KangOphélie GodonMakiko WatanabeGeorge DelidakisCaitlin M. GillisDelphine SterlinDavid HardyMichel CognéLynn E. MacdonaldAndrew J. MurphyNaxin TuJiwon LeeJonathan R. McDanielEmily MakowskiPeter M. TessierAaron S. MeyerPierre BruhnsGeorge GeorgiouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chang-Han Lee Tae Hyun Kang Ophélie Godon Makiko Watanabe George Delidakis Caitlin M. Gillis Delphine Sterlin David Hardy Michel Cogné Lynn E. Macdonald Andrew J. Murphy Naxin Tu Jiwon Lee Jonathan R. McDaniel Emily Makowski Peter M. Tessier Aaron S. Meyer Pierre Bruhns George Georgiou An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
description	Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitulate the key processes for antibody persistence in circulation.
format	article
author	Chang-Han Lee Tae Hyun Kang Ophélie Godon Makiko Watanabe George Delidakis Caitlin M. Gillis Delphine Sterlin David Hardy Michel Cogné Lynn E. Macdonald Andrew J. Murphy Naxin Tu Jiwon Lee Jonathan R. McDaniel Emily Makowski Peter M. Tessier Aaron S. Meyer Pierre Bruhns George Georgiou
author_facet	Chang-Han Lee Tae Hyun Kang Ophélie Godon Makiko Watanabe George Delidakis Caitlin M. Gillis Delphine Sterlin David Hardy Michel Cogné Lynn E. Macdonald Andrew J. Murphy Naxin Tu Jiwon Lee Jonathan R. McDaniel Emily Makowski Peter M. Tessier Aaron S. Meyer Pierre Bruhns George Georgiou
author_sort	Chang-Han Lee
title	An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
title_short	An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
title_full	An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
title_fullStr	An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
title_full_unstemmed	An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
title_sort	engineered human fc domain that behaves like a ph-toggle switch for ultra-long circulation persistence
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/84d23b07351d4847b7e49dca2fbb568c
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An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

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