Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
Abstract Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia (AML). We have performed a high-throughput screening searching for...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/84e9066a4962437e9c1ac1b64a684a28 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|